CLINICAL AND MICROBIOLOGICAL FEATURES OF SALMONELLA INFECTION CAUSED BY S. ENTERICA SUBSP. ENTERICA SEROVAR ENTERITIDIS STRAINS WITH DIFFERENT PLASMID PROFILESAbstracts of the 11th Australian Food Microbiology Conference, 28 March, 2003. Australia, 2003.
Variation in clinical manifestations of Salmonella infection is frequently explained by the variety of Salmonella serovars (Saphra I. et al., 1957). The difference in the severity of illness was shown to be connected with a presence of serovar-specific virulence plasmid in some Salmonella serovars (Libby S.J. et al., 1997).
During 1988-1992 the plasmid variant of Salmonella enterica subsp. enterica serovar Enteritidis (further S. Enteritidis), having single plasmid with a molecular weight of 38 MDa was dominated in the Primorskiy Region. Appearing in July 1995 a new pathogen with plasmid profile 38:1.4 MDa has essentially affected disease incidence within the population. We've established that S. enteritidis with separate plasmid profiles in the clinical and epidemiological features of an infection are peculiar characteristics for each of them. The total disease incidence caused by all S. Enteritidis reflects only the quantity indicators of illness whereas pathogens with separate plasmid profile disease dynamics are peculiar characteristics for each. The clinics of the S. enteritidis infection with plasmid profile of 38:1.4 MDa differs from clinics of S. enteritidis infection with plasmid profile of 38 MDa has the propensity to development of long diarrhea syndrome with expressed repeated vomiting, development of hypovolemic and infective-toxic shocks and acute renal failure. Cases of carriers were not registered. Presence of the specified differences allows considering that the investigated strains with above mentioned plasmid profiles represent various clones of S. enteritidis.
Hence, epidemiological features and variation in clinical manifestation of a Salmonella infection can be the result of an infection caused by various clones of one serovar of a microbe. It is probable that the given features of S. enteritidis, with plasmid profile 38:1.4 MDa, are determined by its higher virulence for humans, underlies the clinical and epidemiological manifestation of infection. Thus, the given results allow for the conclusion that manifestation of the above mentioned syndromes in clinics of a Salmonella infection are determined by features of the pathogen instead of a macro organism.
Principal and presenting author (Alexey Vladimirovich Rakov MD PhD) e-mail: vokar@mailru.com Principal and presenting author (Alexey Vladimirovich Rakov MD PhD) fax: +7 (4232) 441438